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Literature summary extracted from

  • Nguyen, T.K.; Arungundram, S.; Tran, V.M.; Raman, K.; Al-Mafraji, K.; Venot, A.; Boons, G.J.; Kuberan, B.
    A synthetic heparan sulfate oligosaccharide library reveals the novel enzymatic action of D-glucosaminyl 3-O-sulfotransferase-3a (2012), Mol. Biosyst., 8, 609-614.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.23 expressed in Sf9 insect cells Homo sapiens
2.8.2.30 expressed in Sf9 insect cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.23 Homo sapiens
-
-
-
2.8.2.30 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.23 Toyopearl AF-heparin 650M column chromatography Homo sapiens
2.8.2.30 Toyopearl AF-heparin 650M column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.23 3'-phosphoadenylyl sulfate + GlcA-beta-(1->4)-GlcNS6S-beta-(1->4)-GlcA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 Homo sapiens adenosine 3',5'-bisphosphate + GlcA-beta-(1->4)-GlcNS3S6S-beta-(1->4)-GlcA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 ?
2.8.2.23 3'-phosphoadenylyl sulfate + GlcA-beta-(1->4)-GlcNS6S-beta-(1->4)-IdoA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 Homo sapiens adenosine 3',5'-bisphosphate + GlcA-beta-(1->4)-GlcNS3S6S-beta-(1->4)-IdoA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 ?
2.8.2.23 3'-phosphoadenylyl sulfate + GlcA-beta-(1->4)-GlcNS6S-beta-(1->4)-IdoA-beta-(1->4)-GlcNS6S-beta-(1->4)-GlcA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 Homo sapiens adenosine 3',5'-bisphosphate + GlcA-beta-(1->4)-GlcNS3S6S-beta-(1->4)-IdoA-beta-(1->4)-GlcNS3S6S-beta-(1->4)-GlcA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 ?
2.8.2.23 3'-phosphoadenylyl sulfate + GlcA-beta-(1->4)-GlcNS6S-beta-(1->4)-IdoA2S-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 Homo sapiens adenosine 3',5'-bisphosphate + GlcA-beta-(1->4)-GlcNS3S6S-beta-(1->4)-IdoA2S-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 ?
2.8.2.23 3'-phosphoadenylyl sulfate + IdoA-beta-(1->4)-GlcNS6S-beta-(1->4)-IdoA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 Homo sapiens adenosine 3',5'-bisphosphate + IdoA-beta-(1->4)-GlcNS3S6S-beta-(1->4)-IdoA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 ?
2.8.2.30 3'-phosphoadenylyl sulfate + GlcA-beta-(1->4)-GlcNS6S-beta-(1->4)-IdoA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 Homo sapiens adenosine 3',5'-bisphosphate + GlcA-beta-(1->4)-GlcNS3S6S-beta-(1->4)-IdoA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 ?
2.8.2.30 3'-phosphoadenylyl sulfate + GlcA-beta-(1->4)-GlcNS6S-beta-(1->4)-IdoA-beta-(1->4)-GlcNS6S-beta-(1->4)-GlcA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 Homo sapiens adenosine 3',5'-bisphosphate + GlcA-beta-(1->4)-GlcNS3S6S-beta-(1->4)-IdoA-beta-(1->4)-GlcNS3S6S-beta-(1->4)-GlcA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 ?
2.8.2.30 3'-phosphoadenylyl sulfate + IdoA-beta-(1->4)-GlcNS6S-beta-(1->4)-IdoA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 Homo sapiens adenosine 3',5'-bisphosphate + IdoA-beta-(1->4)-GlcNS3S6S-beta-(1->4)-IdoA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2
-
 ?
2.8.2.30 additional information GlcA-beta-(1->4)-GlcNS6S-beta-(1->4)-GlcA-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2 and GlcA-beta-(1->4)-GlcNS6S-beta-(1->4)-IdoA2S-beta-(1->4)-GlcNS6S-alpha-(CH2)5NH2 are no substrates for isoform 3-OST-3a Homo sapiens ?
-
 ?
2.8.2.30 additional information isoform 3-OST3a preferentially sulfates the GlcNS6S residue when an iduronic acid residue is located to its reducing side, while 2-O-sulfation of this iduronic acid inhibits the action of isoform 3-OST3a on the target residue Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.23 3-OST-1
-
 Homo sapiens
2.8.2.23 heparan sulfate 3-O-sulfotransferase 1
-
 Homo sapiens
2.8.2.30 3-OST-3A
-
 Homo sapiens
2.8.2.30 D-glucosaminyl 3-O-sulfotransferase-3a
-
 Homo sapiens